Excessive Respiratory Modulation of Blood Pressure Triggers Hypertension

C Menuet; S Le; B Dempsey; AA Connelly; JL Kamar; N Jancovski; JK Bassi; K Walters; AE Simms; A Hammond; AY Fong; AK Goodchild; S McMullan; AM Allen

Journal article

Excessive Respiratory Modulation of Blood Pressure Triggers Hypertension

C Menuet, S Le, B Dempsey, AA Connelly, JL Kamar, N Jancovski, JK Bassi, K Walters, AE Simms, A Hammond, AY Fong, AK Goodchild, S McMullan, AM Allen

Cell Metabolism | CELL PRESS | Published : 2017

DOI: 10.1016/j.cmet.2017.01.019

Abstract

The etiology of hypertension, the world's biggest killer, remains poorly understood, with treatments targeting the established symptom, not the cause. The development of hypertension involves increased sympathetic nerve activity that, in experimental hypertension, may be driven by excessive respiratory modulation. Using selective viral and cell lesion techniques, we identify adrenergic C1 neurons in the medulla oblongata as critical for respiratory-sympathetic entrainment and the development of experimental hypertension. We also show that a cohort of young, normotensive humans, selected for an exaggerated blood pressure response to exercise and thus increased hypertension risk, has enhanced ..

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University of Melbourne Researchers

Angela Connelly Author

Jaspreet Bassi Author

Angelina Fong Author

Andrew Allen Author

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Grants

Awarded by University of Bristol

Funding Acknowledgements

We thank Professor J.F. Paton, University of Bristol, for his expert comments on the manuscript. This work was supported by grant funding from the National Health and Medical Research Council of Australia (APP#1029396 and #1102477) and the Australian Research Council (DP1094301 and DP120100920). C.M. was supported by a McKenzie Research Fellowship from the University of Melbourne.